The book itself I can't say much about yet since I've not read it, but it is I Says, Says I; a novel, by Thinks-I-To-Myself (i.e. Edward Nares). This is the first American edition, published at Boston by Bradford & Read and Philadelphia by Anthony Finley [printed at Boston by Munroe & Francis], dated 17 October 1812 (the first edition was published at London, also in 1812). A light penciled note on the title page appears to read "Trash, Trash" (which may be an indication of the quality of the text - you can judge for yourself if you wish, since Google Books has scanned this edition).
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No, the interesting thing about this book is the signature(s) on the title page (pictured at left, full-size version here). The upper signature reads "Jean Skipwith / Prestwould", and the other (in red ink faded to a very bright pink) "Lionel Skipwith - 1895."
I've written about Lady Jean Skipwith (1748-1826) before (here), after I finished adding her library to LibraryThing. She was the most voracious female book collector in early America; her library included a vast number of novels and other literary writings (I suspect she had a fair majority of all English novels written by women during her lifetime; check out her author cloud). In her will she left 200 volumes each to her daughter-in-law Sarah Nivison Skipwith (wife of her son Humberston) and her two daughters Helen and Selena.
Sarah Nivison Skipwith having died before her mother-in-law, the books meant for her were apparently given to her widower, Jean's son Humberston Skipwith (1791-1862). From there this novel likely passed to Humberston's son Grey (1840-1895), and from him to his son Lionel (1882-1918); the date of Lionel's signature coincides with the year of his father's death.
So this book has quite a story (to me, an irresistible one, in fact), and that's why it's now on my shelves.